LMK-235 (Fandachem)
LMK 235
CAS: 1418033-25-6
Molecular Formula: C15H22N2O4
LMK-235 (Fandachem) - Names and Identifiers
| Name | LMK 235 |
| Synonyms | LMK235 CS-1820 LMK 235 LMK-235 LMK 235 LMK-235 (Fandachem) N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-benzamide Benzamide, N-[[6-(hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl- N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethylbenzamide LMK-235 |
| CAS | 1418033-25-6 |
| EINECS | 808-770-7 |
| InChIKey | VRYZCEONIWEUAV-UHFFFAOYSA-N |
LMK-235 (Fandachem) - Physico-chemical Properties
| Molecular Formula | C15H22N2O4 |
| Molar Mass | 294.35 |
| Density | 1.155±0.06 g/cm3(Predicted) |
| Melting Point | 135-138°C |
| Solubility | Soluble in DMSO |
| Appearance | powder |
| Color | white to beige |
| pKa | 9.46±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Use | LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor. LMK-235 demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 = 0.49 and 0.32 μ M respectively). |
| Target | HDAC4; HDAC5; |
LMK-235 (Fandachem) - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
LMK-235 (Fandachem) - Reference
| Reference Show more | 1: Hansen FK, Sumanadasa SD, Stenzel K, Duffy S, Meister S, Marek L, Schmetter R, Kuna K, Hamacher A, Mordmüller B, Kassack MU, Winzeler EA, Avery VM, Andrews KT, Kurz T. Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages. Eur J Med Chem. 2014 Jul 23;82:204-13. doi: 10.1016/j.ejmech.2014.05.050. Epub 2014 May 22. PubMed PMID: 24904967. 2: Marek L, Hamacher A, Hansen FK, Kuna K, Gohlke H, Kassack MU, Kurz T. Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. J Med Chem. 2013 Jan 24;56(2):427-36. doi: 10.1021/jm301254q. Epub 2013 Jan 8. PubMed PMID: 23252603. |
LMK-235 (Fandachem) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.397 ml | 16.987 ml | 33.973 ml |
| 5 mM | 0.679 ml | 3.397 ml | 6.795 ml |
| 10 mM | 0.34 ml | 1.699 ml | 3.397 ml |
| 5 mM | 0.068 ml | 0.34 ml | 0.679 ml |
Last Update：2024-01-02 23:10:35
LMK-235 (Fandachem) - Cell Experiment
The rate of cell survival under the action of test substances is evaluated by an improved MTT assay. The assay is based on the ability of viable cells to metabolize yellow MTT to violet formazan that can be detected spectrophotometrically. In brief, A2780, Cal27, Kyse510, and MDA-MB-231 cell lines are seeded at a density of 5000, 7000, 8000, and 10 000 cells/well in 96-well plates. After 24 h, cells are exposed to increased concentrations of the test compounds. Incubation is ended after 72 h, and cell survival is determined by addition of MTT solution (5 mg/mL in phosphate buffered saline). The formazan precipitate is dissolved in DMSO. Absorbance s measured at 544 and 690 nm in a FLUOstar microplate reader. (Only for Reference)
Last Update：2023-08-16 21:32:38
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View History
LMK-235 (Fandachem)
(4-甲氧基羰基-2,6-二甲基-苯基)9,10-二氢吖啶-9-羧酸酯
胆碱碳酸氢盐
ETHYNYLMAGNESIUM BROMIDE
Lithium acetoacetate
ETHYL 12-HYDROXYSTEARATE
甘氨酸铝锆
硼酸盐磷酸盐缓冲液 溶液
ISO-THIAZOLINONE(KATHON)
(4-甲氧基羰基-2,6-二甲基-苯基)9,10-二氢吖啶-9-羧酸酯
胆碱碳酸氢盐
ETHYNYLMAGNESIUM BROMIDE
Lithium acetoacetate
ETHYL 12-HYDROXYSTEARATE
甘氨酸铝锆
硼酸盐磷酸盐缓冲液 溶液
ISO-THIAZOLINONE(KATHON)